identify the antidote for benzodiazepine poisoning

These patients had high benzodiazepine serum blood concentrations. 01) after the injection of 0.7 +/- 0.3 mg of flumazenil. Seventy-five percent of the aggregated controlled and uncontrolled patients awoke from coma scores of 3.1 +/- 0.6 to 0.4 +/- 0.5 (p <.

Treatment continued by boluses or infusion as long as efficacious.įourteen of 17 double-blind, flumazenil-treated patients woke after a mean of 0.8 +/- 0.3 (SD) mg vs. Patients remaining unconscious among double-blind patients or those patients relapsing into coma after the first dose were later treated in the open phase of the study. The first 31 double-blind patients received either intravenous flumazenil (to a maximum of 1 mg) or saline, while the rest of the patients were given flumazenil until either regaining consciousness or a maximum of 2.5 mg was injected. Blood pressure, electrocardiogram, respiratory rate, end-tidal CO2, and core temperature were continuously monitored. A peripheral intravenous cannula was inserted, as were indwelling arterial and urinary bladder catheters.

INTERVENTIONS All patients received supplemental oxygen endotracheal intubation was performed, and synchronized intermittent mandatory ventilation was initiated whenever it was deemed necessary. The first 31 patients were studied in a double-blind fashion, while the rest of the patients were given flumazenil according to an open protocol. Unconscious patients (n = 110) suspected of benzodiazepine overdose, graded 2 to 4 on the Matthew and Lawson coma scale, were treated with flumazenil, the specific benzodiazepine receptor antagonist. other drug-induced coma), and to reverse or prevent the recurrence of unconsciousness.Ī two-phase study: a controlled, randomized, double-blind study followed by a prospective, open study.Īn 800-bed, teaching, university-affiliated hospital.

To assess the efficacy, usefulness, safety, and dosages of flumazenil required when flumazenil is used in the diagnosis of benzodiazepine-induced coma (vs.

Identify the antidote for benzodiazepine poisoning